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KMID : 0369820070370020095
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 2 p.95 ~ p.99
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In vitro Release Characteristics of Nitroglycerin from Microemulsion-Based Hydrogel System for Anal Fissure Treatment
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Lee Sang-Kil
Shin Hyun-Woo
Kang Myung-Joo
Cho Seong-Wan
Cho Jae-Youl
Lee Jae-Hwi
Choi Young-Wook
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Abstract
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To develop topical nitroglycerin (NTG) preparation far chronic anal fissure treatment, the release rate of NTG should be controlled carefully. For this, microemulsion was prepared from the phase diagram construction with Cremophor ELP, ethanol and Labrafil $M1944CS^{(R)}$ and the topical gel was prepared by dispersing NTG containing microemulsion into hydrophilic polymers. in viかo release characteristics were evaluated with Franz diffusion cell using cellulose membrane and compared with control hydrogels. The release rate of NTG was followed $1^{st}$ order kinetics and, when comparing the NTG release from control hydrogel with that from the microemulsion-based hydrogel, the NTG release rate was controlled by the content of polymers within continuous phase and the concentration of dispersed phase.
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KEYWORD
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Nitroglycerin, Mictroemulsion, Hydrogel, Controlled release, Anal fissure
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